*EPF513 11/08/2002
Text: Faster Results Available from Newly Approved HIV Test Kit
(Test results in as little as 20 minutes, no special equipment needed) (930)

The U.S. Food and Drug Administration approved a new test for the detection of the HIV virus November 7, with the prediction that faster results will encourage more testing, more detection and more prevention of the disease.

The OraQuick Rapid HIV-1 Antibody Test manufactured by OraSure Technologies Incorporated can provide results on the presence of the virus in a person's blood in as little as 20 minutes. The test kit can be stored at room temperature, and testing requires no specialized equipment, according to an FDA news release, and so "may be considered for use outside of traditional laboratory or clinical settings."

In its corporate press release, OraSure Technologies calls the new product "an important advance for rapid diagnostic testing."

Health and Human Services Secretary Tommy Thompson said the fast results the test provides might be an incentive to encourage more people to get tested. "Each year, 8,000 HIV-infected people who come to public clinics for HIV testing do not return a week later to receive their test results," Thompson said. "With this new test, in less than a half an hour they can learn preliminary information about their HIV status, allowing them to get the care they need to slow the progression of their disease and to take precautionary measures to help prevent the spread of this deadly virus."

OraSure Spokesperson Bill Bruckner said in a Washington File interview that marketing and distributing the new test internationally is a company priority, though he was unable to project a time-frame in which that might happen. The company must submit the product to the regulatory agencies of other countries, each of which has different procedures and different requirements, Bruckner said. OraSure, a small Pennsylvania-based company, would also seek a partnership with a larger international company to ensure a successful marketing and distribution campaign for the product.

Following is the text of the FDA release:

(begin text)

U.S. FOOD AND DRUG ADMINISTRATION

FDA APPROVES NEW RAPID HIV TEST KIT

November 7, 2002

HHS Secretary Tommy G. Thompson today announced that the U.S. Food and Drug Administration has approved a new rapid HIV diagnostic test kit that provides results with 99.6 percent accuracy in as little as 20 minutes.

Using less than a drop of blood collected, this new test can quickly and reliably detect antibodies to HIV-1, the HIV virus that causes infection in most cases in the U.S. Unlike other antibody tests for HIV, this test can be stored at room temperature, requires no specialized equipment, and may be considered for use outside of traditional laboratory or clinical settings. The newly approved HIV test is called The OraQuick Rapid HIV-1 Antibody Test, manufactured by OraSure Technologies, Inc., Bethlehem, Pennsylvania.

"Each year, 8,000 HIV-infected people who come to public clinics for HIV testing do not return a week later to receive their test results," Secretary Thompson said. "With this new test, in less than a half an hour they can learn preliminary information about their HIV status, allowing them to get the care they need to slow the progression of their disease and to take precautionary measures to help prevent the spread of this deadly virus."

To perform the test, a fingerstick sample of blood is collected from an individual and transferred to a vial where it is mixed with a developing solution. The test device, which resembles a dipstick, is then inserted into the vial. In as little as 20 minutes, the test device will indicate if HIV-1 antibodies are present in the solution by displaying two reddish-purple lines in a small window on the device. Although the results of rapid screenings will be reported in point-of-care settings, as with all screening tests for HIV, if the OraQuick test gives a reactive test result, that result must be confirmed with an additional specific test. The OraQuick test has not been approved to screen blood donors.

FDA currently categorizes the OraQuick test as "moderate complexity" under the Clinical Laboratory Improvements Amendments of 1988 (CLIA). Under CLIA, new tests are categorized as either moderate or high complexity. This designation means that the OraQuik test can only be given in CLIA-approved labs by CLIA-certified laboratory technicians or medical staff. If the test manufacturer applies for a CLIA waiver, the FDA can evaluate it for use under less stringent conditions.

"I strongly urge the OraSure company to apply for a CLIA waiver," said Secretary Thompson, "If the FDA finds that the company's data proves that the OraQuick test is both easy and safe to use, it can get a CLIA waiver. Then the test could be given in many more health care settings, perhaps even administered by social workers in HIV counseling centers. But the process can't begin until OraSure applies for the waiver, so I ask them to please apply now!"

The Centers for Disease Control and Prevention (CDC) has estimated that one fourth of the approximately 900,000 HIV-infected people in the U.S. are not aware that they are infected. Because of the potential public health benefits of rapid HIV testing, the CDC and the Centers for Medicare and Medicaid Services (CMS) are working with state and other health officials to make the test widely available and to offer technical assistance and counseling training for its use. "This test will be a great help in identifying pregnant HIV-infected women going into labor who were not tested during pregnancy so that precautionary steps can be take to block their newborns from being infected with HIV," said FDA Deputy Commissioner Dr. Lester M. Crawford. "It will also be a critical resource in helping identify HIV infection in health-care and emergency workers who are accidentally exposed to HIV-infected blood while doing their job."

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(Distributed by the Office of International Information Programs, U.S. Department of State. Web site: http://usinfo.state.gov)

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